Epstein-Barr virus Diagnostics

VCA-markers p18 and p40:

(first filed: 10-03-1993)

  • For diagnosis of EBV carrier status (+/-) and diagnosis of acute, chronic and malignant disease through detection of anti-VCA IgM, IgG and IgA antibodies
  • MoAb for detection of EBV antigen in body fluids and tissues
  • Seq. recombinant antigen and detection of EBV genome and mRNA

Europe(DE,FR,CH,AT,BE,SE,IT,DK,ES,PT,IE,GB,NL): EP0574048, dd.14-08-2002.
Finland: FI114802,dd.31-12-2004,
Australia: AU666920, dd.09-07-1996
New Zealand: NZ225077, dd.09-07-1996
USA: US5424398,dd.13-06-1995, US6008327, dd.28-12-1999, US6365717, dd.02-04-2002
Japan: JP4135996, dd.13-062008, JP4365440, dd.28-08-2009
Indonesia: ID006034,dd.15-03-2001
Hong Kong: HK1001221, dd.30-01-2003
Korea: KR0291247, dd.09-03-2001
South Africa: ZA931797, dd.29-12-1993

EBNA1 immunodominant peptides:

(first filed: 13-09-1993)

  • For diagnosis of EBV carrier status (+/-) and diagnosis of acute, chronic and malignant disease through detection of anti-EBNA1 IgM, IgG and IgA antibodies
  • MoAb for detection of EBV antigen in body fluids and tissues
  • Seq. recombinant antigen and detection of EBV genome and mRNA

Europe (DE,FR,CH,AT,BE,SE,IT,DK,ES,PT,IE,GB,NL): EP0607425, dd.12-05-2004.
Finland: FI114781 dd.31-12-2004,
Australia: AU667745, dd.13-08-1996
USA: US5965353 dd.12-10-1999
Canada: 2120342, dd.16-11-2004
Japan: JP4155591 dd.07-18-2008, JP4368406, dd.09-04-2009
Hong Kong: HK1001461, dd.14-01-2005
Korea: KR0384250, dd.02-05-2003

EAd immunodominant peptides:

(first filed: 28-05-1996)

  • For diagnosis of EBV carrier status (+/-) and diagnosis of acute, chronic and malignant disease through detection of anti-EBNA1 IgM, IgG and IgA antibodies
  • MoAb for detection of EBV antigen in body fluids and tissues
  • Seq. recombinant antigen and detection of EBV genome and mRNA

Europe (DE,FR,CH,AT,BE,SE,IT,DK,ES,PT,IE,GB,FI,NL): EP0747481, dd.19-12-2001.
Australia: AU707301, dd.21-10-1999
USA: US5843405 dd.01-12-1998, US6143865, dd.07-11-2000
Canada: 2178057, dd.07-12-1996
Japan: JP4319703 dd.5-06-2009
Hong Kong: HK1001164, dd.14-06-2002
Korea: KR0523972, dd.19-10-2005
Indonesia: ID0009429, dd.19-12-2002

Multiplex use of VCA/MA+EBNA1 in single assay format:

(first filed: 09-09-1994)

  • For one-step diagnosis of EBV carrier status (+/-) and diagnosis of acute, chronic and malignant disease through detection of anti-EBV IgM, IgG and IgA antibodies
  • MoAb for detection of EBV antigen in body fluids and tissues

Europe: (DE,FR,CH,AT,BE,SE,IT,DK,ES,PT,IE,GB,FI,NL): EP-0649904, dd.22-01-2003
Finland: FI113298, dd.31-02-2004
Australia: AU679545, dd. 23-10-1997
USA: US5827646, dd.27-10-1998
Canada: CA2131874, dd.28-03-2006
Japan: JP3547493, dd.23-04-2004
Korea: KR0378942, dd.24-03-2003
Hong Kong: 1001222, dd.21-11-2003
Indonesia: ID008232, dd.23-03-1995 (pending)

Primers & probes for EBV nucleic acid detection:

(first filed 01-03-1999)

  • Seq. for detection of EBV genome and mRNA; combi EBNA1, LMP1, BARF1
  • For tumor diagnosis and definition viral activity, carcinoma or lymphoma

Europe: (DE,FR,CH,AT,BE,SE,IT,DK,ES,PT,IE,GB,FI,NL): EP-1060271, dd.22-04-2009
Australia: AU757404, dd. 19-06-2003
USA: US7026112, dd.11-04-2006
Canada: WO9945155, dd.10-09-2009 pending
Japan: WO9945155, dd.10-09-2009, pending
Korea: WO9945155, dd.10-09-2009, pending
Hong Kong: WO9945155, dd.10-09-2009, pending
Indonesia: WO9945155, dd.10-09-2009, pending

Therapeutic & Vaccine Applications

Epstein-Barr virus:

  • Seq. and use of EBV- LMP1 -LMP2 and BARF1 extracellular domains for tumor vaccination and antibody-based therapeutics

Europe: (DE,FR,CH,AT,BE,SE,IT,DK,ES,PT,IE,GB,FI,NL): (PCT)EP02-00997, dd. 01-30-2002, pending
USA: US7811581, dd.12-10-2010
China: ZL02807469.6, dd.07-09-2011
Indonesia: WO2003-01651, dd.26-10-2011, pending